Clomid (clomiphene citrate) is the antiestrogen of choice for improving the restoration of natural testosterone production after a cycle, improving testosterone production by endurance athletes and is also effective in reducing the risk of gynecomastia during a cycle with aromatizable steroids It is claimed that Clomid "stimulates" production of LH and therefore testosterone, in reality Clomid`s activity is not achieved by stimulating the hypothalamus and pituitary glands, but by blocking their inhibition by estrogen.

Clomid is a mixed estrogen agonist / antagonist (activator / blocker) that, when attached to the estrogen receptor, brings it into a slightly different conformation (shape) than estradiol. The estrogen receptor requires the binding of an estrogen or drug at its binding site and also the binding of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor / clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist - the cofactor used in that tissue cannot bind and so the receptor remains inactive - and in others Clomid acts as an agonist (activator) because of the cofactors that are used in that tissue , are able to bind. Clomid is a potent antagonist in the hypothalamus and breast tissue. It is an effective agonist in bone tissue and for improving cholesterol-cholesterol. Clomid also has the property of reducing the adverse effects of exercise-induced damage to muscle tissue. This is very important for endurance athletes, but is not very significant, if at all, with proper weight training. Clomid did not perceptibly affect the weight trainer's gains either favorably or adversely in my experience.

The drug appears to have estrogenic effects on mood, which can be beneficial (improving relationships with women by improving empathy) or can cause depression or PMS-like symptoms, but for most users there is no significant effect either way. The claim that the duration of use should not be more than 10-14 days is wrong. Clinical studies in male patients were for periods of one year or longer. This flaw presumably stems from the fact that for use in women, due to the menstrual cycle, there would obviously be no point in encouraging ovulation every four weeks of the month. Use in women is limited to 10-14 days. This limitation is not because of toxicity.

Clomid is indeed useful during a cycle when using aromatizable drugs. However, we think that to be conservative, use it no more than 2/3 of the time all year or a little less.